Multicellular Spheroid Culture Models: Applications in prostate Cancer Research and Therapeutics

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Live Multicellular Tumor Spheroid Models For High-Content Imaging and Screening In Cancer Drug Discovery

The multi cellular tumor spheroid (MCTS) model has been used for decades with proven superiority over monolayer cell culture models at recapitulating in vivo tumor growth. Yet its use in high-throughput drug discovery has been limited, particularly with image based screening, due to practical and technical hurdles. Here we report a significant advance in utilizing live MCTS models for high-cont...

متن کامل

Molecular therapeutics in prostate cancer.

The purpose of this review is to provide information on the molecular basis of prostate cancer biology and to identify some of the targets for therapy, and highlight some potential strategies for molecular treatment. Here we give a synopsis of what we have learned regarding molecular biology of cancer in general and the directions research might take in the future in order to impact prostate ca...

متن کامل

Cancer-Associated Fibroblasts Modify the Response of Prostate Cancer Cells to Androgen and Anti-Androgens in Three-Dimensional Spheroid Culture

Androgen receptor (AR) targeting remains the gold standard treatment for advanced prostate cancer (PCa); however, treatment resistance remains a major clinical problem. To study the therapeutic effects of clinically used anti-androgens we characterized herein a tissue-mimetic three-dimensional (3D) in vitro model whereby PCa cells were cultured alone or with PCa-associated fibroblasts (CAFs). N...

متن کامل

Agent-Based Simulations of In Vitro Multicellular Tumor Spheroid Growth

Multicellular tumor spheroids (MTS) are an in vitro model system of avascular tumors. They are used to study how local microenvironments affect cellular growth, viability, and therapeutic response. We are developing in silico, agent-based analogues to provide new options for gaining exploitable insight into both the in vitro and in vivo systems. MTS exhibit characteristic phenotypic attributes:...

متن کامل

Current mouse and cell models in prostate cancer research.

Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an androgen-regulated fusion protein, revealed its role in developing PCa precurs...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Cancer Science & Therapy

سال: 2011

ISSN: 1948-5956

DOI: 10.4172/1948-5956.1000059